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COVID vaccines from Pfizer, Moderna, J&J & Novavax code for a “Stabilised Spike”. Why did they stabilise the Spike and have Oxford AZ made a mistake by not stabilising the Spike?

The most effective vaccines generate neutralising antibody which prevents the virus from attaching to our cells. A virus can’t infect our cells if it can’t attach to (fuse with) our body cells. If the virus can not infect our cells it will not cause disease.    The COVID causing virus has spike proteins on itsContinue reading “COVID vaccines from Pfizer, Moderna, J&J & Novavax code for a “Stabilised Spike”. Why did they stabilise the Spike and have Oxford AZ made a mistake by not stabilising the Spike?”

Study looks at the impact of Stabilising SARS-Cov-2 Spike through “PP” mutations and Cleavage site removal. Combination of PP and Cleavage site removal (as seen in J&J/Novavax vaccine) was beneficial, “PP” mutation alone (as seen in Pfizer/Moderna) was not

The spike protein of (SARS-CoV-2) the virus that causes COVID is the prime focus of vaccine development. The spike protein enables both binding to host cells and membrane fusion and is the only known viral target of neutralizing antibodies.  The virus spike protein needs to be in the pre-fusion conformation in order to attach toContinue reading “Study looks at the impact of Stabilising SARS-Cov-2 Spike through “PP” mutations and Cleavage site removal. Combination of PP and Cleavage site removal (as seen in J&J/Novavax vaccine) was beneficial, “PP” mutation alone (as seen in Pfizer/Moderna) was not”

Highly promising early effectiveness data for a single dose of the Pfizer and Oxford AstraZeneca vaccines from Public Health England

Early estimates of the effectiveness of the Pfizer and Oxford AstraZeneca vaccines by Public Health England. Data shows efficacy against symptomatic COVID disease (confirmed by positive test). This data was based upon people vaccinated who wee aged 70or over. Pfizer vaccine demonstrates an estimated Efficacy of 61% between 28-34 days after 1st dose. Oxford AstraZenecaContinue reading “Highly promising early effectiveness data for a single dose of the Pfizer and Oxford AstraZeneca vaccines from Public Health England”

What does Vaccine Efficacy actually mean?

Public Health Scotland & University of Edinburgh study showed the Pfizer/BioNTech vaccine reduced hospitalisations by 85% and 94% for the Oxford AstraZeneca vaccine. It is important to recognise that this is still early data but it is still highly encouraging. What does Vaccine Efficacy actually mean? The headline figures for Vaccine Efficcacy released over theContinue reading “What does Vaccine Efficacy actually mean?”

Just published in the Medical journal, The Lancet:

“New exploratory analyses suggest 3-month interval between doses of Oxford AstraZeneca vaccine results in higher efficacy than 6-week interval, with first dose offering 76% protection in the 3 months between doses” Just published in the Medical journal, The Lancet: “New exploratory analyses suggest 3-month interval between doses of Oxford AstraZeneca vaccine results in higher efficacyContinue reading “Just published in the Medical journal, The Lancet:”

Harvard study suggests B.1.1.7 🇬🇧 may result in more Infections by increasing the time a person remains infectious. If this is the case it would significantly reduce the challenge in reopening schools and hospitality venues.

Harvard did a comparison study between individuals infected with B.1.1.7🇬🇧 variant and the original virus variant. Their aim was to try and determine why the virus was more transmissible (why on average a person infected with B.1.1.7🇬🇧 infects more people than the original variant. They looked to see whether it was connected with individuals releasing largerContinue reading “Harvard study suggests B.1.1.7 🇬🇧 may result in more Infections by increasing the time a person remains infectious. If this is the case it would significantly reduce the challenge in reopening schools and hospitality venues.”

A summary of the findings of the Oxford University investigation into the impact of utilising the Native Virus Spike over a Stabilised Spike in their COVID vaccine

Adenovirus-vectored vaccines offer an effective platform for the delivery of viral antigen, but it is important for the generation of neutralizing antibodies that they produce appropriately processed and assembled viral antigen that mimics that observed on the SARS-CoV-2 virus. The Spike (S) protein is responsible for mediating host-cell entry, with the S1 and S2 subunitsContinue reading “A summary of the findings of the Oxford University investigation into the impact of utilising the Native Virus Spike over a Stabilised Spike in their COVID vaccine”

What do we know about the Variant Under Investigation in the UK, B.1.525?

B.1.525 was first sequenced on the 15th December. The Origin of Virus variant is yet to be determined with UK🇬🇧 or Nigeria🇳🇬 thought to be most likely. 38 cases of this variant have since been detected in the UK. It has been detected through genome sequencing in 10 countries in total including Denmark, the USContinue reading “What do we know about the Variant Under Investigation in the UK, B.1.525?”

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