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Welcome to COVID Data review

A blog by a Biological Sciences Lecturer and tutor, dedicated to reviewing the latest COVID data

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COVID vaccines from Pfizer, Moderna, J&J & Novavax code for a “Stabilised Spike”. Why did they stabilise the Spike and have Oxford AZ made a mistake by not stabilising the Spike?

The most effective vaccines generate neutralising antibody which prevents the virus from attaching to our cells. A virus can’t infect our cells if it can’t attach to (fuse with) our body cells. If the virus can not infect our cells it will not cause disease.    The COVID causing virus has spike proteins on itsContinue reading “COVID vaccines from Pfizer, Moderna, J&J & Novavax code for a “Stabilised Spike”. Why did they stabilise the Spike and have Oxford AZ made a mistake by not stabilising the Spike?”

Study looks at the impact of Stabilising SARS-Cov-2 Spike through “PP” mutations and Cleavage site removal. Combination of PP and Cleavage site removal (as seen in J&J/Novavax vaccine) was beneficial, “PP” mutation alone (as seen in Pfizer/Moderna) was not

The spike protein of (SARS-CoV-2) the virus that causes COVID is the prime focus of vaccine development. The spike protein enables both binding to host cells and membrane fusion and is the only known viral target of neutralizing antibodies.  The virus spike protein needs to be in the pre-fusion conformation in order to attach toContinue reading “Study looks at the impact of Stabilising SARS-Cov-2 Spike through “PP” mutations and Cleavage site removal. Combination of PP and Cleavage site removal (as seen in J&J/Novavax vaccine) was beneficial, “PP” mutation alone (as seen in Pfizer/Moderna) was not”

Highly promising early effectiveness data for a single dose of the Pfizer and Oxford AstraZeneca vaccines from Public Health England

Early estimates of the effectiveness of the Pfizer and Oxford AstraZeneca vaccines by Public Health England. Data shows efficacy against symptomatic COVID disease (confirmed by positive test). This data was based upon people vaccinated who wee aged 70or over. Pfizer vaccine demonstrates an estimated Efficacy of 61% between 28-34 days after 1st dose. Oxford AstraZenecaContinue reading “Highly promising early effectiveness data for a single dose of the Pfizer and Oxford AstraZeneca vaccines from Public Health England”

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